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Ufd1 (基因名), Ubiquitin recognition factor in ER-associated degradation protein 1 (蛋白名), ufd1_rat.
产品名称:

Rat Ufd1/ Ubiquitin recognition factor in ER-associated degradation protein 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Ubiquitin fusion degradation protein 1 homolog, UB fusion protein 1, Ufd1l

检测方法:
ELISA
特异性:
Natural and recombinant rat Ubiquitin recognition factor in ER-associated degradation protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Rat Ufd1 ELISA Kit
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Rat Ufd1 ELISA Kit
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通用注释


亚单元:
Interacts with USP13 (By similarity). Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion (PubMed:10811609). Interacts with ZFAND2B; probably through VCP (By similarity).


功能:
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (PubMed:10811609). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).


亚细胞位置:
Nucleus Cytoplasm Cytosol


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