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Uimc1 (基因名), BRCA1-A complex subunit RAP80 (蛋白名), uimc1_rat.
产品名称:

Rat Uimc1/ BRCA1-A complex subunit RAP80 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Receptor-associated protein 80, Ubiquitin interaction motif-containing protein 1, Rap80

检测方法:
ELISA
特异性:
Natural and recombinant rat BRCA1-A complex subunit RAP80
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Uimc1 ELISA Kit
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Rat Uimc1 ELISA Kit
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产品说明书
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通用注释


亚单元:
Interacts with TSP57 (By similarity). Component of the ARISC complex, at least composed of UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1, NR6A1 and UBE2I.


功能:
Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.


亚细胞位置:
Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).


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