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Ulk3 (基因名), Serine/threonine-protein kinase ULK3 (蛋白名), ulk3_mouse.
产品名称:

Mouse Ulk3/ Serine/threonine-protein kinase ULK3 ELISA Kit

货号:

E4579m

商标:
EIAab®
监管等级:
别名:

Unc-51-like kinase 3

检测方法:
ELISA
特异性:
Natural and recombinant mouse Serine/threonine-protein kinase ULK3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Mouse Ulk3 ELISA Kit
规格 & 价格: cart
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Mouse Ulk3 ELISA Kit
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亚单元:
Interacts (via protein kinase domain) with SUFU.


功能:
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.


亚细胞位置:
Cytoplasm Localizes to pre-autophagosomal structure during cellular senescence.


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