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UNC13A (基因名), Protein unc-13 homolog A (蛋白名), un13a_human.
产品名称:

Human UNC13A/ Protein unc-13 homolog A ELISA Kit
蛋白unc-13同源物A

货号:

E14841h

商标:
EIAab®
监管等级:
别名:

Munc13-1, KIAA1032

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.098ng/mL
特异性:
Natural and recombinant human Protein unc-13 homolog A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human UNC13A ELISA Kit
规格 & 价格: cart
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Human UNC13A ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with the N-termini of STX1A and/or STX1B1 and DOC2A. Interacts with BSN. Interacts with RIMS1 which recruits UNC13A to the active zone. Forms homodimers via its first C2 domain. Also interacts via this domain with the zinc finger domain of RIMS2. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Also part of a complex consisting of UNC13A, RIMS2 and RAB3A.


功能:
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).


亚细胞位置:
Cytoplasm Cell membrane Peripheral membrane protein Cell junction Synapse Presynaptic cell membrane Peripheral membrane protein Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity).


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