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ABCG2 (基因名), ATP-binding cassette sub-family G member 2 (蛋白名), abcg2_human.

产品名称:

ABCG2 Antibody
腺苷三磷酸结合盒转运蛋白G2

货号:

M0960Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCP, BCRP, BCRP1, MXR

反应性:

human

免疫原:

Recombinant human ABCG2 protein ( R0960h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human ABCG2 Monoclonal Antibody

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R&D 技术数据

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通用注释

亚单元:

Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.

功能:

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.

亚细胞位置:

Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein

数据库链接

UniGene:

Hs.480218

STRING:

9606.ENSP00000237612

KEGG:

hsa:9429

MIM:

138900

Pfam: