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AIFM1 (基因名), Apoptosis-inducing factor 1, mitochondrial (蛋白名), aifm1_human.

产品名称:

AIFM1 Antibody
凋亡诱导因子1，线粒体

货号:

M1064Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Programmed cell death protein 8, AIF, PDCD8

反应性:

human

免疫原:

Recombinant human AIFM1 protein ( R1064h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human AIFM1 Monoclonal Antibody

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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

Monomer (oxidized form). Homodimer (reduced form). Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1.

功能:

Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

亚细胞位置:

Isoform 5 Cytoplasm

数据库链接

UniGene:

Hs.424932

SMR:

O95831

STRING:

9606.ENSP00000287295

KEGG:

hsa:9131

MIM: