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ANGPTL3 (基因名), Angiopoietin-related protein 3 (蛋白名), angl3_human.

产品名称:

ANGPTL3 Antibody
Angiopoietin-related蛋白3

货号:

M1699Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Angiopoietin-5, Angiopoietin-like protein 3, ANG-5, UNQ153/PRO179, ANGPT5

反应性:

human, mouse

免疫原:

Recombinant human ANGPTL3 protein ( R1699h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human ANGPTL3 Monoclonal Antibody

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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

Interacts with ANGPTL8. Interacts with ITGB3.

功能:

Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (PubMed:11877390). Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (PubMed:18535744). May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS.

亚细胞位置:

Secreted Cell projection Lamellipodium Colocalized with HSPG2 and activated ITGB3 on podocytes.

数据库链接

UniGene:

Hs.209153

STRING:

9606.ENSP00000360170

KEGG:

hsa:27329

MIM:

604774

Pfam: