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ATG12 (基因名), Ubiquitin-like protein ATG12 (蛋白名), atg12_human.

产品名称:

ATG12 Antibody
类泛素蛋白ATG12

货号:

M2478Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Autophagy-related protein 12, APG12-like, APG12, APG12L

反应性:

human,mouse,rat

免疫原:

Recombinant human ATG12 protein ( R2478h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human ATG12 Monoclonal Antibody

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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

Forms a conjugate with ATG5. The ATG12-ATG5 conjugate forms a complex with several units of ATG16L. Interacts with ATG3, ATG7 and ATG10. ATG12-ATG5 also interacts with MAVS, MGA, RARRES3 and TECPR1.

功能:

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

亚细胞位置:

Cytoplasm Preautophagosomal structure membrane Peripheral membrane protein TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.

数据库链接

UniGene:

Hs.264482

SMR:

O94817

STRING:

9606.ENSP00000425107

KEGG:

hsa:9140

MIM: