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BRCA2 (基因名), Breast cancer type 2 susceptibility protein (蛋白名), brca2_human.

产品名称:

BRCA2 Antibody
乳腺癌2型易感蛋白

货号:

M1364Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Fanconi anemia group D1 protein, FACD, FANCD1

反应性:

human, rat,mouse

免疫原:

Recombinant human BRCA2 protein ( R1364h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human BRCA2 Monoclonal Antibody

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R&D 技术数据

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通用注释

亚单元:

Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with SEM1; the interaction masks a nuclear export signal in BRCA2. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SEM1 (PubMed:24896180, PubMed:21719596).

功能:

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).

亚细胞位置:

Nucleus Cytoplasm Cytoskeleton Microtubule organizing center Centrosome

数据库链接

UniGene:

Hs.34012

SMR:

P51587

STRING:

9606.ENSP00000369497

KEGG:

hsa:675

MIM:

114480

Pfam:

PF09169

Uniprot:

P51587

相关产品

Mouse Brca2 ELISA Kit

序列长度:

3418

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TEECEKNKQD | TITTKKYI

3D 模型:

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BRCA2 Antibody乳腺癌2型易感蛋白

M1364Rb

Fanconi anemia group D1 protein, FACD, FANCD1

BRCA2 Antibody
乳腺癌2型易感蛋白