DDX42 (基因名), ATP-dependent RNA helicase DDX42 (蛋白名), ddx42_human.
产品名称:
DDX42 Antibody
ATP依赖RNA解旋酶DDX42
货号:
M14799Rb-h
商标:
EIAab®
监管等级:
别名:
DEAD box protein 42, RNA helicase-like protein, RNA helicase-related protein, SF3b DEAD box protein, Splicing factor 3B-associated 125 kDa protein, RHELP, RNAHP, SF3b125
反应性:
human
免疫原:
Recombinant human DDX42 protein ( R14799h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
-
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of p53/TP53.
功能:
ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
亚细胞位置:
Cytoplasm
Nucleus speckle
Nucleus
Cajal body
Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.
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