GDF15 (基因名), Growth/differentiation factor 15 (蛋白名), gdf15_human.
产品名称:
GDF15 Antibody
生长分化因子15
货号:
M2034Rb
商标:
EIAab®
监管等级:
别名:
Macrophage inhibitory cytokine 1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor, MIC-1, NAG-1, NRG-1, GDF-15, MIC1, PDF, PLAB, PTGFB
反应性:
human,mouse
免疫原:
corresponding to a sequence mapping at the 30-308aa of Q99988
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cancer
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Homodimer; disulfide-linked (PubMed:29046435). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).
功能:
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
亚细胞位置:
Secreted
[1].
[2].
Tao Sun, ; Yanbo Huang, ; M. Ian Phillips, ; Xinping Luo, ; Jun Zhu,Haiming Shi, ; Jian Li,
From:
Clinical Investigations
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