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GDF5 (基因名), Growth/differentiation factor 5 (蛋白名), gdf5_human.

产品名称:

GDF5 Antibody
生长分化因子5

货号:

M0550Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Bone morphogenetic protein 14, Cartilage-derived morphogenetic protein 1, Lipopolysaccharide-associated protein 4, Radotermin, BMP-14, CDMP-1, LAP-4, GDF-5, BMP14, CDMP1

反应性:

human

免疫原:

corresponding to a sequence mapping at the 28-381aa of P43026

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human GDF5 Monoclonal Antibody

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通用注释

亚单元:

Homodimer; disulfide-linked (By similarity). Interacts with serine proteases, HTRA1 and HTRA3 (By similarity). Following LPS binding, may form a complex with CXCR4, HSP90AA1 and HSPA8. Interacts with high affinity with NOG; inhibits chondrogenesis. Interacts with high affinity with BMPR1B and lower affinity with BMPR1A; positively regulates chondrocyte differentiation and induces SMAD dependent signaling. Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).

功能:

Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).

亚细胞位置:

Secreted Cell membrane

数据库链接

UniGene:

Hs.1573

SMR:

P43026

STRING:

9606.ENSP00000363489

KEGG:

hsa:8200

MIM: