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OLR1 (基因名), Oxidized low-density lipoprotein receptor 1 (蛋白名), olr1_human.
产品名称:

OLR1 Antibody
氧化低密度脂蛋白受体1

货号:

M1859Rb-h

商标:
EIAab®
监管等级:
别名:

C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX-1, Ox-LDL receptor 1, CLEC8A, LOX1

反应性:
human
免疫原:
Recombinant human OLR1 protein ( R1859h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cardiovascular
Human OLR1 Monoclonal Antibody
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通用注释


亚单元:
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.


功能:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.


亚细胞位置:
Cell membrane Lipid-anchor Cell membrane Single-pass type II membrane protein Membrane raft Secreted A secreted form also exists. Localization to membrane rafts requires palmitoylation.


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