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PEG10 (基因名), Retrotransposon-derived protein PEG10 (蛋白名), peg10_human.

产品名称:

PEG10 Antibody
逆转录转座子衍生蛋白PEG10

货号:

M3142Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein, MEF3-like protein 1, EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3

反应性:

human, mouse

免疫原:

Recombinant human PEG10 protein ( R3142h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human PEG10 Monoclonal Antibody

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R&D 技术数据

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通用注释

亚单元:

Interacts with ALK1, SIAH1 and SIAH2.

功能:

Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.

亚细胞位置:

Nucleus Cytoplasm Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.

数据库链接

UniGene:

Hs.147492

STRING:

9606.ENSP00000417587

KEGG:

hsa:23089

MIM:

609810

Pfam:

PF16297

Uniprot: