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PIM2 (基因名), Serine/threonine-protein kinase pim-2 (蛋白名), pim2_human.

产品名称:

PIM2 Antibody
丝氨酸/苏氨酸蛋白激酶Pim-2

货号:

M5627Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Pim-2h

反应性:

human

免疫原:

Recombinant human PIM2 protein ( R5627h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human PIM2 Monoclonal Antibody

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通用注释

亚单元:

Interacts with MYC.

功能:

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

亚细胞位置:

N/A

数据库链接

UniGene:

Hs.727148

SMR:

Q9P1W9

STRING:

9606.ENSP00000365692

KEGG:

hsa:11040

MIM: