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PINK1 (基因名), Serine/threonine-protein kinase PINK1, mitochondrial (蛋白名), pink1_human.

产品名称:

PINK1 Antibody
线粒体丝氨酸/苏氨酸蛋白激酶PINK1基因

货号:

M15235Rb

商标:

EIAab^®

监管等级:

RUO

别名:

BRPK, PTEN-induced putative kinase protein 1

反应性:

human, mouse

免疫原:

corresponding to a sequence mapping at the 260-465aa of Q9BXM7

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human PINK1 Monoclonal Antibody

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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

Interacts with PARK2. Interacts with FBXO7. Forms a complex with PARK2 and PARK7 (PubMed:19229105).

功能:

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).

亚细胞位置:

Mitochondrion outer membrane Single-pass membrane protein Cytoplasm Cytosol Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol.

数据库链接

UniGene:

Hs.389171

STRING:

9606.ENSP00000364204

KEGG:

hsa:65018

MIM:

168600

Pfam:

PF00069

Uniprot: