TAP2 (基因名), Antigen peptide transporter 2 (蛋白名), tap2_human.
产品名称:
TAP2 Antibody
抗原肽转运蛋白2
货号:
M10018Rb-h
商标:
EIAab®
监管等级:
别名:
ATP-binding cassette sub-family B member 3, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter TAP2, Peptide transporter involved in antigen processing 2, Really interesting new gene 11 protein, PSF-2, APT2, ABCB3, PSF2, RING11, Y1
反应性:
human
免疫原:
Recombinant human TAP2 protein ( R10018h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
-
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Interacts with herpes simplex virus ICP47 (PubMed:7760936).
功能:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
亚细胞位置:
Endoplasmic reticulum membrane
Multi-pass membrane protein
The transmembrane segments seem to form a pore in the membrane.
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