VCL (基因名), Vinculin (蛋白名), vinc_human.
产品名称:
VCL Antibody
货号:
M1839Rb-h
商标:
EIAab®
监管等级:
别名:
Metavinculin, MV
反应性:
human
免疫原:
Recombinant human VCL protein ( R1839h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cardiovascular
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Exhibits self-association properties. Interacts with APBB1IP and NRAP (By similarity). Interacts with TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity). Interacts with SYNM. Interacts with SORBS1 (By similarity). Interacts with CTNNA1 (PubMed:26691986). Binds to ACTN4; this interaction triggers conformational changes (PubMed:15988023).
功能:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
亚细胞位置:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell junction
Adherens junction
Cell junction
Focal adhesion
Cytoplasm
Cytoskeleton
Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
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