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WT1 (基因名), Wilms tumor protein (蛋白名), wt1_human.
产品名称:

WT1 Antibody
肾母细胞瘤蛋白

货号:

M11563Rb

商标:
EIAab®
监管等级:
别名:

WT33

反应性:
human,mouse,rat
免疫原:
Recombinant human WT1 protein ( R11563h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cancer
  • Human WT1 Monoclonal Antibody
  • Human WT1 Monoclonal Antibody
  • Human WT1 Monoclonal Antibody
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Human WT1 Monoclonal Antibody
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R&D 技术数据
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通用注释


亚单元:
Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2 (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with AMER1. Interacts with RBM4.


功能:
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).


亚细胞位置:
Isoform 4 Nucleus Nucleoplasm


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