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ADAM10 (基因名), Disintegrin and metalloproteinase domain-containing protein 10 (蛋白名), ada10_human.

产品名称:

ADAM10 Antibody

货号:

P0766Rb

商标:

EIAab^®

监管等级:

RUO

别名:

CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM 10, KUZ, MADM

序列号:

O14672

反应性:

human,mouse

免疫原:

corresponding to a sequence mapping at the C-terminal of O14672

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human ADAM10 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Jurkat whole cell was subjected to SDS-PAGE followed by Western Blot with Disintegrin and metalloproteinase domain-containing protein 10antibody at dilution of 1:300

Immunohistochemical analysis of paraffin-embedded human lung Papillary adenocarcinoma, using ADAM10 antibody at 1:250 dilution.

通用注释

亚单元:

Interacts with EPHA2 (By similarity). Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells (PubMed:16239146). Interacts with NGF in a divalent cation-dependent manner (PubMed:20164177). Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression (PubMed:26668317, PubMed:26686862). Interacts with TSPAN5, TSPAN10, TSPAN15, TSPAN17 and TSPAN33; these interacations regulate ADAM10 substrate specificity (PubMed:26686862).

功能:

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).

亚细胞位置:

Cell membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

数据库链接

UniGene:

Hs.172028

SMR:

O14672

STRING:

9606.ENSP00000260408

KEGG:

hsa:102

MIM:

602192

Pfam: