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ADRB2 (基因名), Beta-2 adrenergic receptor (蛋白名), adrb2_human.

产品名称:

ADRB2 Antibody

货号:

P9974Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2R, B2AR

序列号:

P07550

反应性:

human,mouse,rat

免疫原:

Recombinant human ADRB2 protein ( R9974h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Signal Transduction

规格 & 价格:

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Human ADRB2 Polyclonal Antibody

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产品说明书

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R&D 技术数据

HeLa cells was subjected to SDS-PAGE followed by Western Blot with Beta-2 adrenergic receptorantibody at dilution of 1:300

Anti-ADRB2 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

通用注释

亚单元:

Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).

功能:

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

亚细胞位置:

Cell membrane Multi-pass membrane protein Early endosome Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).

数据库链接

UniGene:

Hs.2551

SMR:

P07550

STRING:

9606.ENSP00000305372

KEGG:

hsa:154

MIM:

109690

Pfam: