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AIFM1 (基因名), Apoptosis-inducing factor 1, mitochondrial (蛋白名), aifm1_human.
产品名称:

AIFM1 Antibody

货号:

P1064Rb-h

商标:
EIAab®
监管等级:
别名:

Programmed cell death protein 8, AIF, PDCD8

序列号:
O95831
反应性:
human
免疫原:
Recombinant human AIFM1 protein ( R1064h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human AIFM1 Polyclonal Antibody
规格 & 价格: cart
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Human AIFM1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
IHC of paraffin-embedded human breast cancer tissues using AIF antibody with DAB staining.(dilution at 1:250)
通用注释


亚单元:
Monomer (oxidized form). Homodimer (reduced form). Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1.


功能:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.


亚细胞位置:
Isoform 5 Cytoplasm


该产品尚未在任何出版物中被引用。
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