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AIM2 (基因名), Interferon-inducible protein AIM2 (蛋白名), aim2_human.
产品名称:

AIM2 Antibody

货号:

P2139Rb

商标:
EIAab®
监管等级:
别名:

Absent in melanoma 2

序列号:
O14862
反应性:
human, mouse, rat
免疫原:
Recombinant human AIM2 protein ( R2139h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human AIM2 Polyclonal Antibody
规格 & 价格: cart
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Human AIM2 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry of paraffin-embedded human testis tissue using AIM2 antibody at dilution of 1:100
通用注释


亚单元:
Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform. Component of the AIM2 inflammasome. Interacts with PYCARD, IFI16, EIF2AK2/PKR and MAPRE1.


功能:
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.


亚细胞位置:
Nucleus Cytoplasm Activated inflammasomes can aggregate in the cytosol as speck-like particles.


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