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AKT1S1 (基因名), Proline-rich AKT1 substrate 1 (蛋白名), akts1_human.

产品名称:

AKT1S1 Antibody

货号:

P14177Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

40 kDa proline-rich AKT substrate, PRAS40

序列号:

Q96B36

反应性:

human

免疫原:

Recombinant human AKT1S1 protein ( R14177h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human AKT1S1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC of paraffin-embedded human brain tissue, using Akt1 S1 Antibody at a dilution of 1:200.

通用注释

亚单元:

Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Interacts directly with RPTOR. The phosphorylated form interacts with 14-3-3 proteins.

功能:

Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.

亚细胞位置:

Cytoplasm Cytosol Found in the cytosolic fraction of the brain.

数据库链接

UniGene:

Hs.515542

SMR:

Q96B36

STRING:

9606.ENSP00000341698

KEGG:

hsa:84335

MIM: