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ARC (基因名), Activity-regulated cytoskeleton-associated protein (蛋白名), arc_human.

产品名称:

ARC Antibody

货号:

P7736Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Activity-regulated gene 3.1 protein homolog, ARC/ARG3.1, hArc, KIAA0278

序列号:

Q7LC44

反应性:

human

免疫原:

corresponding to a sequence mapping at the 1-240aa of Q7LC44

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human ARC Polyclonal Antibody

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R&D 技术数据

Immunohistochemistry of Human thyroid cancer using ARC Polyclonal Antibody at dilution of 1:25.

通用注释

亚单元:

Homooligomer; homooligomerizes into virion-like capsids (PubMed:25748042). Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity). Interacts with CAMK2B (in the kinase inactive state); leading to target ARC to inactive synapses (By similarity). Interacts with PSEN1 (By similarity).

功能:

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).

亚细胞位置:

Extracellular vesicle membrane Lipid-anchor Cell junction Synapse Postsynaptic cell membrane Lipid-anchor Cell junction Synapse Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Early endosome membrane Cell projection Dendrite Cytoplasm Cytoskeleton Cytoplasm Cell cortex Cell projection Dendritic spine Cytoplasmic vesicle Secretory vesicle Acrosome Forms virion-like extracellular vesicles that are released from neurons. Enriched in postsynaptic density of dendritic spines. Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state. Accumulation at weaker synapses may be required to prevent their undesired enhancement. Associated with the cell cortex of neuronal soma and dendrites (By similarity). Associated with the sperm tail (By similarity).

数据库链接

UniGene:

Hs.40888

SMR:

Q7LC44

STRING:

9606.ENSP00000349022

KEGG:

hsa:23237

MIM:

612461

Uniprot: