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ATR (基因名), Serine/threonine-protein kinase ATR (蛋白名), atr_human.

产品名称:

ATR Antibody

货号:

P15117Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, FRP1

序列号:

Q13535

反应性:

human,mouse,rat

免疫原:

corresponding to a sequence mapping at the 2296-2644 of Q13535

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human ATR Polyclonal Antibody

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产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
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R&D 技术数据

ATR antibody detects ATR protein at nucleus on human ovarian carcinoma by immunohistochemical analysis. ATR antibody diluted at 1:250.

通用注释

亚单元:

Interacts with ATRIP; forming a heterodimer with ATRIP (PubMed:11721054). Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with BCR-ABL after genotoxic stress. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164. Interacts with TELO2 and TTI1.

功能:

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

亚细胞位置:

Nucleus Nucleus PML body Chromosome Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.

数据库链接

UniGene:

Hs.271791

STRING:

9606.ENSP00000343741

KEGG:

hsa:545

MIM:

210600

Pfam:

PF02259

Uniprot:

Q13535

相关产品

Mouse Atr ELISA Kit

Mouse Atr CLIA Kit

Mouse Atr Protein

Mouse Atr Polyclonal Antibody

Mouse Atr Monoclonal Antibody

序列长度:

2644

序列:

仅供参考，详细请咨询（services@eiaab.com）

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2644:

GVIKTRNRVT | GLPLSIEGHV | HYLIQEATDE | NLLCQMYLGW | TPYM

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

多克隆抗体ATR可以申请产品的免费试用装吗？

我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同，我们将提供换货或退款服务。如果抗体用于未测试的物种或应用，我们不提供换货或退款服务。EIAab产品的投诉期为6个月，逾期不予受理。

[2].

多克隆抗体ATR说明书上的信息是及时更新的吗？

说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时，说明书会实时更新，因此说明书绝不会过时。

[3].

如何选择合适的一抗？

请先确定您要检测的种属和使用的实验方法，然后查找相关产品，根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测，则您可以放心地购买该产品。

[4].

多克隆抗体ATR在其他物种或应用中测试过吗？

所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后，就会立即更新物种和应用。

[5].

如何保存多克隆抗体ATR？

我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存，我们不能保证抗体的性能。

[6].

如何分装多克隆抗体ATR？

请根据一次实验的常用量进行分装。每等份不应少于10μl；每等份的量越少，抗体储液浓度受蒸发和管壁吸附的影响越大。

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