BIRC5 (基因名), Baculoviral IAP repeat-containing protein 5 (蛋白名), birc5_human.
产品名称:
BIRC5 Antibody
货号:
P2045Rb-h
商标:
EIAab®
监管等级:
别名:
Apoptosis inhibitor 4, Apoptosis inhibitor survivin, API4, IAP4
序列号:
O15392
反应性:
human
免疫原:
corresponding to a sequence mapping at the 1-142aa of O15392
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
R&D 技术数据
通用注释
亚单元:
Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8 (PubMed:17956729). Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.
功能:
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
亚细胞位置:
Cytoplasm
Nucleus
Chromosome
Chromosome
Centromere
Cytoplasm
Cytoskeleton
Spindle
Chromosome
Centromere
Kinetochore
Midbody
Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export.
该产品尚未在任何出版物中被引用。
[1].
多克隆抗体BIRC5可以申请产品的免费试用装吗?
我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同,我们将提供换货或退款服务。如果抗体用于未测试的物种或应用,我们不提供换货或退款服务。EIAab产品的投诉期为6个月,逾期不予受理。
[2].
多克隆抗体BIRC5说明书上的信息是及时更新的吗?
说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时,说明书会实时更新,因此说明书绝不会过时。
[3].
如何选择合适的一抗?
请先确定您要检测的种属和使用的实验方法,然后查找相关产品,根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测,则您可以放心地购买该产品。
[4].
多克隆抗体BIRC5在其他物种或应用中测试过吗?
所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后,就会立即更新物种和应用。
[5].
如何保存多克隆抗体BIRC5?
我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存,我们不能保证抗体的性能。
[6].
如何分装多克隆抗体BIRC5?
请根据一次实验的常用量进行分装。每等份不应少于10μl;每等份的量越少,抗体储液浓度受蒸发和管壁吸附的影响越大。
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