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BIRC6 (基因名), Baculoviral IAP repeat-containing protein 6 (蛋白名), birc6_human.
产品名称:

BIRC6 Antibody

货号:

P0308Rb-h

商标:
EIAab®
监管等级:
别名:

BIR repeat-containing ubiquitin-conjugating enzyme, RING-type E3 ubiquitin transferase BIRC6, Ubiquitin-conjugating BIR domain enzyme apollon, BRUCE, APOLLON, KIAA1289

序列号:
Q9NR09
反应性:
human
免疫原:
Recombinant human BIRC6 protein ( R0308h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human BIRC6 Polyclonal Antibody
规格 & 价格: cart
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Human BIRC6 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Detection of Human BIRC6/Apollon by Immunohistochemistry. Antibody: Affinity purified rabbit anti-BIRC6/Apollon used at a dilution of 1:5000 (0.2 ug/ml).
通用注释


亚单元:
Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.


功能:
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.


亚细胞位置:
Golgi apparatus Trans-Golgi network membrane Midbody Endosome Cytoplasm Cytoskeleton Spindle pole Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.


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