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CALR (基因名), Calreticulin (蛋白名), calr_human.

产品名称:

CALR Antibody

货号:

P1486Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

CRP55, Calregulin, Endoplasmic reticulum resident protein 60, HACBP, grp60, ERp60, CRTC

序列号:

P27797

反应性:

human

免疫原:

Recombinant human CALR protein ( R1486h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human CALR Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC analysis of formalin fixed paraffin-embedded (FFPE) human prostate cancer using Calreticulin antibody at 1:50.

通用注释

亚单元:

Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21 (PubMed:8666824). Interacts with NR3C1 (PubMed:11149926). Interacts with PPIB (PubMed:20801878). Interacts (via P-domain) with PDIA5 (PubMed:23614004). Interacts with GABARAP (PubMed:19154346).

功能:

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.

亚细胞位置:

Endoplasmic reticulum lumen Cytoplasm Cytosol Secreted Extracellular space Extracellular matrix Cell surface Sarcoplasmic reticulum lumen Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). Associated with the lytic granules in the cytolytic T-lymphocytes.

数据库链接

UniGene:

Hs.515162

SMR:

P27797

STRING:

9606.ENSP00000320866

KEGG:

hsa:811

MIM:

109091

Pfam: