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CASP4 (基因名), Caspase-4 (蛋白名), casp4_human.

产品名称:

CASP4 Antibody

货号:

P1735Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

ICE and Ced-3 homolog 2, ICE(rel)-II, Mih1, Protease TX, ICH-2, CASP-4, ICH2

序列号:

P49662

反应性:

human

免疫原:

Recombinant human CASP4 protein ( R1735h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human CASP4 Polyclonal Antibody

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产品说明书

数据表:

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R&D 技术数据

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CASP4 antibody at dilution of 1:100.

通用注释

亚单元:

(Microbial infection) Interacts with NleF protein from pathogenic E.coli; this interaction leads to enzyme inhibition.

功能:

Inflammatory caspase (PubMed:7797510, PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630, PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:24879791, PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:25121752). In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:7743998, PubMed:7797592, PubMed:7797510).

亚细胞位置:

Cytoplasm Cytosol Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Mitochondrion Inflammasome Secreted Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630).

数据库链接

UniGene:

Hs.138378

SMR:

P49662

STRING:

9606.ENSP00000388566

KEGG:

hsa:837

MIM:

602664

Pfam: