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CASP14 (基因名), Caspase-14 (蛋白名), caspe_human.

产品名称:

CASP14 Antibody

货号:

P2284Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

CASP-14

序列号:

P31944

反应性:

human

免疫原:

Recombinant human CASP14 protein ( R2284h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human CASP14 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemistry of CASP14 in human liver tissue with CASP14 antibody at 2 μg/ml.

通用注释

亚单元:

Heterodimer of a large and a small subunit, both processed from the precursor; the mature active form is a p17/p10 dimer and the intermediate form a p20/p8 dimer.

功能:

Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).

亚细胞位置:

Cytoplasm Nucleus

数据库链接

UniGene:

Hs.466057

SMR:

P31944

STRING:

9606.ENSP00000221740

KEGG:

hsa:23581

MIM: