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CAV1 (基因名), Caveolin-1 (蛋白名), cav1_human.

产品名称:

CAV1 Antibody

货号:

P0214Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

CAV

序列号:

Q03135

反应性:

human

免疫原:

Recombinant human CAV1 protein ( R0214h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human CAV1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

在线询价

数据
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R&D 技术数据

Immunohistochemical microscopy analysis of paraffin-embedded lung carcinoma cell line xenograft tissue using CAV1 antibody.?

通用注释

亚单元:

Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2 (By similarity). Interacts with SLC7A9 (By similarity). Interacts with BMX and BTK. Interacts with TGFBR1 (PubMed:25893292).

功能:

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).

亚细胞位置:

Golgi apparatus membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Membrane Caveola Peripheral membrane protein Membrane raft Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

数据库链接

UniGene:

Hs.74034

SMR:

Q03135

STRING:

9606.ENSP00000339191

KEGG:

hsa:857

MIM:

601047

Pfam: