首页 > 一抗 > CCL5 Antibody

CCL5 (基因名), C-C motif chemokine 5 (蛋白名), ccl5_human.

产品名称:

CCL5 Antibody

货号:

P0116Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

EoCP, Eosinophil chemotactic cytokine, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, TCP228, D17S136E, SCYA5

序列号:

P13501

反应性:

human

免疫原:

corresponding to a sequence mapping at the 24-91aa of P13501

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human CCL5 Polyclonal Antibody

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R&D 技术数据

Staining of formalin fixed, paraffin embedded human breast invasive ductal carcinoma with Rabbit anti Human CCL5 antibody.

通用注释

亚单元:

N/A

功能:

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.514821

SMR:

P13501

STRING:

9606.ENSP00000293272

KEGG:

hsa:6352

MIM: