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CD2AP (基因名), CD2-associated protein (蛋白名), cd2ap_human.

产品名称:

CD2AP Antibody

货号:

P2545Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Adapter protein CMS, Cas ligand with multiple SH3 domains

序列号:

Q9Y5K6

反应性:

human,mouse

免疫原:

Recombinant human CD2AP protein ( R2545h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human CD2AP Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

CD2AP antibody detects CD2AP protein at cytosol on mouse colon by immunohistochemical analysis.

通用注释

亚单元:

Self-associates. Homodimer (Potential). Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET (inactive) and CBLC; upon RET activation by GDNF suggested to dissociate from RET as CBLC:CD2AP complex.

功能:

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

亚细胞位置:

Cytoplasm Cytoskeleton Cell projection Ruffle Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.

数据库链接

UniGene:

Hs.485518

SMR:

Q9Y5K6

STRING:

9606.ENSP00000352264

KEGG:

hsa:23607

MIM:

604241

Pfam: