首页 > 一抗 > CD44 Antibody

CD44 (基因名), CD44 antigen (蛋白名), cd44_human.

产品名称:

CD44 Antibody

货号:

P0670Rb

商标:

EIAab^®

监管等级:

RUO

别名:

CDw44, Phagocytic glycoprotein I, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-I, ECMR-III, PGP-1, CD44, LHR, MDU2, MDU3, MIC4

序列号:

P16070

反应性:

human, mouse,rat

免疫原:

corresponding to a sequence mapping at the Recombinant Protein of P16070

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human CD44 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

CD44 antibody detects CD44 protein at membrane and cytoplasm on human endometrial carcinoma by immunohistochemical analysis.

通用注释

亚单元:

Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119 (PubMed:19381274).

功能:

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.

亚细胞位置:

Cell membrane Single-pass type I membrane protein Colocalizes with actin in membrane protrusions at wounding edges.

数据库链接

UniGene:

Hs.502328

SMR:

P16070

STRING:

9606.ENSP00000398632

KEGG:

hsa:960

MIM: