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DACH1 (基因名), Dachshund homolog 1 (蛋白名), dach1_human.
产品名称:

DACH1 Antibody

货号:

P2628Rb

商标:
EIAab®
监管等级:
别名:

Dach1, DACH

序列号:
Q9UI36
反应性:
human,mouse,rat
免疫原:
Recombinant human DACH1 protein ( R2628h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human DACH1 Polyclonal Antibody
规格 & 价格: cart
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Human DACH1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of DACH1 staining in human colon cancer tissue using DACH1 antibody.
通用注释


亚单元:
Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4.


功能:
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。
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