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DMPK (基因名), Myotonin-protein kinase (蛋白名), dmpk_human.
产品名称:

DMPK Antibody

货号:

P15231Rb-h

商标:
EIAab®
监管等级:
别名:

DM-kinase, DM1 protein kinase, DMPK, Myotonic dystrophy protein kinase, DMK, MT-PK, DM1PK, MDPK

序列号:
Q09013
反应性:
human
免疫原:
Recombinant human DMPK protein ( R15231h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human DMPK Polyclonal Antibody
规格 & 价格: cart
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Human DMPK Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry-Paraffin: DMPK Antibody Human Heart Tissue, antibody concentration 4 ug/ml.
通用注释


亚单元:
Homodimer; homodimerization stimulates the kinase activity. Interacts with HSPB2; may enhance DMPK kinase activity. Interacts with PLN; phosphorylates PLN. May interact with RAC1; may regulate DMPK kinase activity. Interacts with LMNA; may regulate nuclear envelope stability.


功能:
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.


亚细胞位置:
Isoform 3 Mitochondrion membrane


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