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DVL1 (基因名), Segment polarity protein dishevelled homolog DVL-1 (蛋白名), dvl1_human.

产品名称:

DVL1 Antibody

货号:

P15104Rb

商标:

EIAab^®

监管等级:

RUO

别名:

DSH homolog 1, Dishevelled-1

序列号:

O14640

反应性:

human,mouse

免疫原:

corresponding to a sequence mapping at the Recombinant protein of O14640

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human DVL1 Polyclonal Antibody

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产品说明书

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MSDS:

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R&D 技术数据

DVL1 Antibdy immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue

通用注释

亚单元:

Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Interacts (via PDZ domain) with TMEM88. Interacts with DCDC2. Interacts with FOXK2 (PubMed:25805136).

功能:

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

亚细胞位置:

Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytosol Cytoplasmic vesicle Localizes at the cell membrane upon interaction with frizzled family members.

数据库链接

UniGene:

Hs.731450

SMR:

O14640

STRING:

9606.ENSP00000368169

KEGG:

hsa:1855

MIM:

601365

Pfam: