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EPHA3 (基因名), Ephrin type-A receptor 3 (蛋白名), epha3_human.

产品名称:

EPHA3 Antibody

货号:

P1114Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

EPH-like kinase 4, HEK, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, EK4, Human embryo kinase, Eph-like tyrosine kinase 1, ETK, ETK1, HEK, TYRO4

序列号:

P29320

反应性:

human

免疫原:

Recombinant human EPHA3 protein ( R1114h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human EPHA3 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.

通用注释

亚单元:

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.

功能:

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

亚细胞位置:

Isoform 2 Secreted

数据库链接

UniGene:

Hs.123642

SMR:

P29320

STRING:

9606.ENSP00000337451

KEGG:

hsa:2042

MIM: