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FERMT2 (基因名), Fermitin family homolog 2 (蛋白名), ferm2_human.

产品名称:

FERMT2 Antibody

货号:

P2726Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Kindlin-2, Mitogen-inducible gene 2 protein, Pleckstrin homology domain-containing family C member 1, MIG-2, PH domain-containing family C member 1, KIND2, MIG2, PLEKHC1

序列号:

Q96AC1

反应性:

human

免疫原:

Recombinant human FERMT2 protein ( R2726h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human FERMT2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical of paraffinembedded human ovary tumor using FERMT2 antibody at dilution of 1:100

通用注释

亚单元:

Interacts with ILK (By similarity). Interacts with FBLIM1. Interacts with ITGB1 and ITGB3. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1.

功能:

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

亚细胞位置:

Cytoplasm Cytoplasm Cell cortex Cytoplasm Cytoskeleton Cell junction Focal adhesion Membrane Peripheral membrane protein Cytoplasmic side Cell projection Lamellipodium membrane Peripheral membrane protein Cytoplasmic side Nucleus Cytoplasm Myofibril Sarcomere I band Cell surface Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.

数据库链接

UniGene:

Hs.509343

SMR:

Q96AC1

STRING:

9606.ENSP00000342858

KEGG:

hsa:10979

MIM:

607746

Pfam: