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FKBP8 (基因名), Peptidyl-prolyl cis-trans isomerase FKBP8 (蛋白名), fkbp8_human.
产品名称:

FKBP8 Antibody

货号:

P11198Rb

商标:
EIAab®
监管等级:
别名:

38 kDa FK506-binding protein, FK506-binding protein 8, FKBPR38, Rotamase, 38 kDa FKBP, FKBP-8, PPIase FKBP8, FKBP38

序列号:
Q14318
反应性:
human, mouse
免疫原:
corresponding to a sequence mapping at the Recombinant protein of Q14318
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cardiovascular
Human FKBP8 Polyclonal Antibody
规格 & 价格: cart
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Human FKBP8 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
immunohistochemistry of paraffin-embedded Human colon cancer tissue using (FKBP8 antibody)
通用注释


亚单元:
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.


功能:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.


亚细胞位置:
Isoform 3 Mitochondrion membrane Single-pass membrane protein Cytoplasmic side


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