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FLNC (基因名), Filamin-C (蛋白名), flnc_human.
产品名称:

FLNC Antibody

货号:

P11397Rb-h

商标:
EIAab®
监管等级:
别名:

ABP-280-like protein, ABP-L, Actin-binding-like protein, Filamin-2, Gamma-filamin, FLN-C, ABPL, FLN2

序列号:
Q14315
反应性:
human
免疫原:
Recombinant human FLNC protein ( R11397h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Signal Transduction
Human FLNC Polyclonal Antibody
规格 & 价格: cart
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Human FLNC Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry-Paraffin: FLNC Antibody - Staining of human skin stained with FLNC antibody
通用注释


亚单元:
Homodimer; the filamin repeat 24 and the second hinge domain are important for dimer formation. Interacts with FLNB, INPPL1, ITGB1A, KCND2, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only). Interacts with FBLIM1. Interacts with XIRP1; this interaction is mediated by filamin 20 repeat. Interacts with KY. Interacts with IGFN1 (By similarity). Interacts with MICALL2 (By similarity). Interacts with ANK3. Interacts with SYNPO2.


功能:
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.


亚细胞位置:
Cytoplasm Membrane Peripheral membrane protein Cytoplasm Cytoskeleton Cytoplasm Myofibril Sarcomere Z line A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.


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