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FZD1 (基因名), Frizzled-1 (蛋白名), fzd1_human.
产品名称:

FZD1 Antibody

货号:

P11110Rb-h

商标:
EIAab®
监管等级:
别名:

FzE1, Fz-1

序列号:
Q9UP38
反应性:
human
免疫原:
Recombinant human FZD1 protein ( R11110h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human FZD1 Polyclonal Antibody
规格 & 价格: cart
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Human FZD1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
IHC testing of FFPE human prostate cancer tissue with FZD1 antibody.
通用注释


亚单元:
Interacts with MYOC.


功能:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.


亚细胞位置:
Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。
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