首页 > 一抗 > CD74 Antibody

CD74 (基因名), HLA class II histocompatibility antigen gamma chain (蛋白名), hg2a_human.

产品名称:

CD74 Antibody

货号:

P13627Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, p33, Ii, CD74, DHLAG

序列号:

P04233

反应性:

human

免疫原:

Recombinant human CD74 Protein (R13627h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

关注

Human CD74 Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

Formalin-fixed and paraffin embedded human kidney labeled with Anti-CD74 Polyclonal Antibody.

通用注释

亚单元:

Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules. Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival.

功能:

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

亚细胞位置:

Cell membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Golgi apparatus Trans-Golgi network Endosome Lysosome Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

数据库链接

UniGene:

Hs.436568

SMR:

P04233

STRING:

9606.ENSP00000009530

KEGG:

hsa:972

MIM:

142790

Pfam: