首页 > 一抗 > HIF1AN Antibody

HIF1AN (基因名), Hypoxia-inducible factor 1-alpha inhibitor (蛋白名), hif1n_human.

产品名称:

HIF1AN Antibody

货号:

P0495Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Factor inhibiting HIF-1, Hypoxia-inducible factor asparagine hydroxylase, FIH-1, FIH1

序列号:

Q9NWT6

反应性:

human,mouse,rat

免疫原:

Recombinant human HIF1AN protein ( R0495h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human HIF1AN Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohlstochemistry of paraffin-embedded human kidney using HIF1AN antibody at dilution of 1:300

通用注释

亚单元:

Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4 (By similarity). Interacts with UBE3A. Interacts with ANKS3.

功能:

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

亚细胞位置:

Nucleus Cytoplasm Cytoplasm Perinuclear region Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

数据库链接

UniGene:

Hs.500788

SMR:

Q9NWT6

STRING:

9606.ENSP00000299163

KEGG:

hsa:55662

MIM:

606615

Uniprot: