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MR1 (基因名), Major histocompatibility complex class I-related gene protein (蛋白名), hmr1_human.

产品名称:

MR1 Antibody

货号:

P0910Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Class I histocompatibility antigen-like protein, MHC class I-related gene protein

序列号:

Q95460

反应性:

human,mouse,rat

免疫原:

Recombinant human MR1 protein ( R0910h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human MR1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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通用注释

亚单元:

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex.

功能:

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

亚细胞位置:

Isoform 3 Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

数据库链接

UniGene:

Hs.13500

SMR:

Q95460

STRING:

9606.ENSP00000356552

KEGG:

hsa:3140

MIM:

600764

Pfam: