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HSPA2 (基因名), Heat shock-related 70 kDa protein 2 (蛋白名), hsp72_human.

产品名称:

HSPA2 Antibody

货号:

P9985Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Heat shock 70 kDa protein 2

序列号:

P54652

反应性:

human,mouse,rat

免疫原:

Recombinant human HSPA2 protein ( R9985h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human HSPA2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunoperoxidase of polyclonal antibody to HSPA2 on formalin-fixed paraffin-embedded human colon.

通用注释

亚单元:

Interacts with FKBP6 (PubMed:18529014). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (By similarity). Interacts with FKBP6 (PubMed:18529014).

功能:

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells.

亚细胞位置:

Cytoplasm Cytoskeleton Spindle Colocalizes with SHCBP1L at spindle during the meiosis process.

数据库链接

UniGene:

Hs.432648

SMR:

P54652

STRING:

9606.ENSP00000247207

KEGG:

hsa:3306

MIM: