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HTRA2 (基因名), Serine protease HTRA2, mitochondrial (蛋白名), htra2_human.

产品名称:

HTRA2 Antibody

货号:

P15152Rb

商标:

EIAab^®

监管等级:

RUO

别名:

High temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HtrA2, OMI, PRSS25

序列号:

O43464

反应性:

human,mouse,rat, monkey

免疫原:

Recombinant human HTRA2 protein ( R15152h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human HTRA2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical detection of HTRA2 on Paraffin Embedded Section of breast cancer with HTRA2 antibody.

通用注释

亚单元:

Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce.

功能:

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

亚细胞位置:

Mitochondrion intermembrane space Mitochondrion membrane Single-pass membrane protein Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

数据库链接

UniGene:

Hs.469045

SMR:

O43464

STRING:

9606.ENSP00000258080

KEGG:

hsa:27429

MIM:

168600

Pfam: