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IFITM3 (基因名), Interferon-induced transmembrane protein 3 (蛋白名), ifm3_human.

产品名称:

IFITM3 Antibody

货号:

P10026Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Dispanin subfamily A member 2b, Interferon-inducible protein 1-8U, DSPA2b

序列号:

Q01628

反应性:

human,mouse,rat

免疫原:

Recombinant human IFITM3 protein ( R10026h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human IFITM3 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of huaman fallopian tube using IFITM3 antibody.

通用注释

亚单元:

Interacts with ATP6V0B and CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.

功能:

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

亚细胞位置:

Cell membrane Single-pass type II membrane protein Late endosome membrane Single-pass type II membrane protein Lysosome membrane Single-pass type II membrane protein

数据库链接

UniGene:

Hs.374650

STRING:

9606.ENSP00000382707

KEGG:

hsa:10410

MIM:

605579

Pfam:

PF04505

Uniprot: