首页 > 一抗 > IL36A Antibody

IL36A (基因名), Interleukin-36 alpha (蛋白名), il36a_human.

产品名称:

IL36A Antibody

货号:

P2010Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

FIL1 epsilon, Interleukin-1 epsilon, Interleukin-1 family member 6, IL-1 epsilon, IL-1F6, FIL1E, IL1E, IL1F6

序列号:

Q9UHA7

反应性:

human

免疫原:

corresponding to a sequence mapping at the 6-158aa of Q9UHA7

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human IL36A Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue using IL36A antibody.

通用注释

亚单元:

N/A

功能:

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.278910

SMR:

Q9UHA7

STRING:

9606.ENSP00000259211

KEGG:

hsa:27179

MIM: